Alteration of plasma interleukin-18 level in leukemia patients and its clinical significance.
- Author:
Lu-Qin ZHANG
1
;
Yan JIANG
;
Yu-Lin GUO
;
Hui-Ren ZHAO
Author Information
1. Department of Hematology, The First People's Hospital of Xuzhou, Xuzhou 221002, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Child;
Enzyme-Linked Immunosorbent Assay;
Female;
Humans;
Interferon-gamma;
biosynthesis;
Interleukin-18;
blood;
Leukemia;
blood;
drug therapy;
Male;
Middle Aged
- From:
Journal of Experimental Hematology
2003;11(5):542-543
- CountryChina
- Language:Chinese
-
Abstract:
To explore the alteration of plasma level of IL-18 in patients with leukemia before and after chemotherapy and its clinical significance, the plasma level of IL-18 was determined with ELISA method before and 2 weeks after chemotherapy in 37 leukemia patients, and 18 normal individuals. The results showed that the plasma IL-18 level (153.34 +/- 50.74 pg/ml) in leukemia patients was similar to the level (135.82 +/- 47.00 pg/ml) in normal control, and the IL-18 level in ALL patients was significantly increased (173.3 +/- 34.4 pg/ml), while the IL-18 level in CML patients (111.8 +/- 50.5 pg/ml) was lower than normal level. After chemotherapy, the IL-18 level (100.89 +/- 50.07 pg/ml) was significantly lower than normal level and oneself before treatment. It is concluded that plasma IL-18 levels in leukemia patients are un-homogeneous and IL-18 production decreased after chemotherapy, and immunologic hypofunction in patients with chemotherapy might be related with the decrease of IL-18 and related cytokines.
