Expression of t(11;18) and bcl-10 in gastrointestinal MALT lymphoma.
- Author:
Fei DONG
1
;
Zi-Fen GAO
;
Miao WANG
;
Min LI
;
Hong-Mei JING
;
Xue-Biao HUANG
;
Xiao-Yan KE
Author Information
1. Department of Hematology, The 3rd Hospital, Peking University, Beijing 100083, China.
- Publication Type:Journal Article
- MeSH:
Adaptor Proteins, Signal Transducing;
B-Cell CLL-Lymphoma 10 Protein;
Carrier Proteins;
analysis;
Cell Nucleus;
chemistry;
Chromosomes, Human, Pair 11;
Chromosomes, Human, Pair 18;
Humans;
Immunohistochemistry;
Lymphoma, B-Cell, Marginal Zone;
chemistry;
genetics;
Translocation, Genetic
- From:
Journal of Experimental Hematology
2004;12(1):35-38
- CountryChina
- Language:Chinese
-
Abstract:
To detect chromosome translocation t(11;18) (q21;q21) and the nuclear expression of bcl-10 in gastrointestinal mucosa-associated lymphoid tissue (MALT) lymphoma in Chinese, a possible API2-MALT fusion transcript specific to t(11; 18) (q21; q21) in tumors from 42 cases of primary gastrointestinal lymphoma (29 cases of low grade MALT lymphoma, 13 cases of transformed MALT lymphoma) and 40 cases of diffuse large B cell lymphoma was examined by means of RT-PCR and proved by DNA-sequencing. Bcl-10 expression was examined by immunohistochemical method. The results showed that t(11;18) (q21;q21) was 14% positive in cases of low grade MALT lymphomas and 46% positive in transformed MALT lymphomas, but none in cases of DLBCL. Bcl-10 nuclear expression was seen 61% in low grade MALT and 69% in transformed MALT lymphoma. It was suggested that t(11;18) (q21;q21) was related to the prognosis and development of highly advanced MALT lymphoma but not relevant to DLBCL. Bcl-10 nuclear expressions were not significantly different between these two groups, which remains to be explained.
