Major role of stromal cell derived factor and its receptor CXCR4 in the mobilization and homing of hematopoietic stem/progenitor cells - review.
- Author:
Cheng-Yan WANG
1
;
Zhen-Chuan MIAO
;
Mei-Fu FENG
Author Information
1. The State Key Laboratory of Biomembrane and Membrane biotechnology, Institute of Zoology, Chinese Academy of Sciences, 100080 Beijing, China.
- Publication Type:Journal Article
- MeSH:
Chemokine CXCL12;
Chemokines, CXC;
physiology;
Hematopoietic Stem Cell Mobilization;
Humans;
Receptors, CXCR4;
physiology;
Signal Transduction
- From:
Journal of Experimental Hematology
2004;12(1):115-119
- CountryChina
- Language:Chinese
-
Abstract:
Stromal cell derived factor (SDF), expressing on bone marrow stromal cells is a CXC-type chemokine, which specifically chemoattracts hematopoietic stem cells (HSCs) expressing CXCR4. SDF plays important roles in homing and mobilizing of HSCs. In this paper the regulatory mechanism of SDF/CXCR4 in the HSC migration process is mainly reviewed.
