Influence of interferon type I on dendritic cells in vitro - review.
- Author:
Xin-Hui ZHAI
1
;
Wen-Li ZHAO
Author Information
1. Department of Hematology, Shanxi Clinical Hospital of Xi'an Jiaotong University, Xi'an 710068, China. sunbin@csrc.gov.cn
- Publication Type:Journal Article
- MeSH:
Cells, Cultured;
Dendritic Cells;
drug effects;
immunology;
physiology;
Humans;
Immunophenotyping;
Interferon Type I;
pharmacology
- From:
Journal of Experimental Hematology
2004;12(1):120-124
- CountryChina
- Language:Chinese
-
Abstract:
Dendritic cells(DC) are specialized antigen-presenting cells that prime naive T cells to induce initial immune responses. The immature DC capture and process antigens in the periphery, then emigrate to lymphoid organs. There they complete their maturation by upregulating HLA-I, II molecules, costimulatory molecules (eg. CD80, CD86) and adhesive molecules (eg. CD50, CD54, CD58). More studies showed that in vitro only interferons type I (IFN-alpha, beta) accelerate DC maturation in a dose-dependent manner. The DC induced by IFN type I highly express HLA-A, B, C, HLA-DR, costimulatory molecules and adhesive molecules, and they express enhancing effect of T-cells stimulatory activity in vitro. Progress of research in this field was summarized in this paper.
