Expression and significance of HGAL and LMO2 in follicular lymphoma.
- Author:
Fen ZHANG
1
;
Donglan LUO
;
Xinlan LUO
;
Yu CHEN
;
Jie XU
;
Jie CHEN
;
Hengguo ZHUANG
;
Yanhui LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adaptor Proteins, Signal Transducing; metabolism; Biomarkers, Tumor; metabolism; Germinal Center; Humans; Immunohistochemistry; LIM Domain Proteins; metabolism; Lymphoma, Follicular; metabolism; Neoplasm Proteins; metabolism; Neprilysin; metabolism; Proto-Oncogene Proteins; metabolism; Proto-Oncogene Proteins c-bcl-6; metabolism
- From: Chinese Journal of Pathology 2016;45(2):83-85
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the diagnostic value of HGAL and LMO2 expression and compare with CD10 and bcl-6 in follicular lymphoma (FL).
METHODS63 cases of FL were collected from Guangdong General Hospital. The expression of HGAL, LMO2, CD10 and bcl-6 was assessed by immunohistochemistry.
RESULTSThe expression rates of HGAL, LMO2, CD10 and bcl-6 were 98.4% (62/63), 82.5% (52/63), 82.5% (52/63) and 87.3% (55/63), respectively. The expression rate of HGAL was higher than those of LMO2, CD10 and bcl-6, but the differences were not significant (P>0.05). There was no significant difference in HGAL, LMO2 and bcl-6 expression among FL1, FL2 and FL3 cases. The CD10 expression rate of FL1-3A cases was significantly higher than that of FL3B cases(P<0.01).
CONCLUSIONSHGAL and LMO2, especially HGAL, can be used in FL particularly high grade FL as useful germinal center marker.
