Diagnostic value of STAT6 immunohistochemistry in solitary fibrous tumor/meningeal hemangiopericytoma.
- Author:
Xialing ZHANG
1
;
Haixia CHENG
;
Yun BAO
;
Feng TANG
;
Yin WANG
Author Information
- Publication Type:Journal Article
- MeSH: Antigens, CD; analysis; Antigens, CD34; analysis; Antigens, Differentiation, T-Lymphocyte; analysis; Biomarkers, Tumor; analysis; Diagnosis, Differential; Glial Fibrillary Acidic Protein; analysis; Hemangiopericytoma; chemistry; diagnosis; Humans; Immunohistochemistry; Ki-67 Antigen; analysis; Meningeal Neoplasms; chemistry; diagnosis; Meningioma; chemistry; diagnosis; Neurilemmoma; chemistry; diagnosis; S100 Proteins; analysis; STAT6 Transcription Factor; analysis; Solitary Fibrous Tumors; chemistry; diagnosis; Vimentin; analysis
- From: Chinese Journal of Pathology 2016;45(2):97-101
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the diagnostic role of STAT6 immunohistochemistry in solitary fibrous tumors (SFT)/meningeal hemangiopericytomas (HPC).
METHODEvaluated the expression of STAT6, vimentin, CD34, EMA, PR, S-100, CD56, GFAP and Ki-67 in a cohort of 37 SFT/meningeal HPC, 30 meningiomas and 30 schwannomas by immunohistochemistry staining.
RESULTSAll SFT/meningeal HPC demonstrated nuclear positivity for STAT6, and the proportion of positive tumor cells ranged from 60% to 95%, with no significant difference cases.Vimentin was strongly positive in all cases. CD34, EMA and PR positivity was found in 32 cases, 1 case and 4 cases, respectively.S-100 protein, CD56 and GFAP were negative; Ki-67 labeling index was 1%-8%. However, the meningiomas and schwannomas were negative for STAT6.
CONCLUSIONSSTAT6 is a relatively specific biomarker for SFT/meningeal HPC, and may be used in the diagnosis and differential diagnosis of SFT/meningeal HPC, especially for the atypical cases, and allows the precise pathologic diagnosis of SFT/meningeal HPC.
