Complete atrioventricular septal defect: a clinicopathologic study of 35 cases.
- Author:
Pingping ZHONG
1
;
Yiqun GU
;
Aichun WANG
;
Xiaofei SUN
;
Yingnan WANG
;
Xiaobo ZHANG
;
Junling XIE
Author Information
- Publication Type:Journal Article
- MeSH: Abnormalities, Multiple; genetics; pathology; Autopsy; Chromosome Aberrations; Gestational Age; Heart Septal Defects; Humans; Mitral Valve Insufficiency; genetics; pathology
- From: Chinese Journal of Pathology 2016;45(2):107-110
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the autopsy characteristics, pathologic type, malfomation and genetic characteristics of complete atrioventricular septal defect (CAVSD).
METHODSThirty five cases of CAVSD were collected from Maternal and Child Hospital of Haidian District during Jan.2003 to Jan.2015. Autoptic material, clinical history and chromosome examination were reviewed.
RESULTSAmong 35 cases of CAVSD between 18-38 gestational weeks, there were 26 cases with CAVSD A (74.3%, 26/35), 1 case with CAVSD B (2.8%, 1/35) and 8 cases with CAVSD C (22.8%, 8/35). Only CAVSD malformation was seen in 4 cases (11.4%, 4/35). Multiple malformations were seen in 31 cases (88.6%, 31/35). Combined malformations most frequently occurred in cardiovascular, respiratory and locomotor system. Among 15 cases with chromosome examination, chromosome aberrations was found in 13 cases (13/15) and trisomy-21 was found in 11 cases (11/15).
CONCLUSIONSCAVSD is a rare disease and CAVSD A is the most common type. CAVSD is usually combined with other malformations and chromosome aberrations.
