Expression levels of miR-181c-3p and miR-5692b in esophageal cancer and their clinical significance.
- Author:
Shu CHEN
1
;
Babayi AINIWAER
;
Song QING
;
Ting LIU
;
Zhiping MA
;
Yi SHI
;
Xuelian PANG
;
Wei ZHANG
;
Xinxia LI
2
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma, Squamous Cell; genetics; Esophageal Neoplasms; genetics; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; genetics; Prognosis; Up-Regulation
- From: Chinese Journal of Pathology 2015;44(12):905-909
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expression level and clinical significance of miR-181c-3p and miR-5692b in esophageal cancer.
METHODSThe microRNA (miRNA) profiles of esophageal squamous cell carcinoma were analyzed by miRNA microarray in 55 cases of esophageal cancer. The expression levels of miR-181c-3p and miR-5692b from 55 pairs of tumor tissues and adjacent non-neoplastic tissues were determined by qRT-PCR analysis.
RESULTSBoth miR-181c-3p and miR-5692b were significantly up-regulated in tumor tissues compared with adjacent non-neoplastic tissues. Their expression was also significantly associated with tumor size, depth of invasion and clinical tumor stage (P<0.05). High expression of miR-181c-3p and miR-5692b were significantly associated with poor prognosis (P<0.05). Multivariate Cox regression analysis confirmed that high expression of miR-181c-3p and miR-5692b was poor prognostic indicators in esophageal cancer.
CONCLUSIONSThere are significant correlation between miR-181c-3p/miR-5692b expression, clinicopathologic parameters and prognosis. They represent potential prognostic biomarkers in esophageal squamous cell carcinoma.
