Effects of IAT and MAT chemotherapeutic regimens in patients with refractory or relapsed acute myeloid leukemia.
- Author:
Yi-Ran WANG
1
;
Mei GUO
;
Chang-Lin YU
;
Qi-Yun SUN
;
Jian-Hui QIAO
;
Kai-Xun HU
Author Information
1. Chinese PLA Postgraduate Medical School, Beijing, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Antineoplastic Combined Chemotherapy Protocols;
adverse effects;
therapeutic use;
Child;
Cytarabine;
administration & dosage;
Female;
Granulocyte Colony-Stimulating Factor;
administration & dosage;
Humans;
Leukemia, Myeloid, Acute;
drug therapy;
etiology;
Male;
Middle Aged;
Recurrence;
Retrospective Studies;
Vidarabine;
administration & dosage;
Young Adult
- From:
Journal of Experimental Hematology
2012;20(4):884-888
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study was to investigate effects of IAT and MAT chemotherapeutic regimens treating patients with refractory and relapsed acute myeloid leukemia (AML). 99 patients with refractory and relapsed AML received IAT regimen or MAT regimen as study objects were retrospectively analyzed (56 patients with refractory AML and 43 patients with relapsed AML). Among of them, 28 patients were treated with IAT regimen, and 71 patients received with MAT regimen. The results showed that in 2 groups mentioned above the OR was 65.7%, CR was 49.5%, PR was 16.2%; in IAT group the OR was 64.3%, CR was 46.4%; in MAT group the OR was 66.2%, CR was 50.7%, no statistical difference was found between these 2 groups; The 2 years overall survival was 25% in IAT group and 15.5% in MAT group. Serious infection in IAT and MAT regime groups was 25% and 9.9%, respectively. It is concluded that both IAT and MAT regimens are effective methods for inducing CR in patients with refractory of relapsed AML. IAT and MAT regimens can be used in treatment of the refractory or relapsed MAL patients who were not respond to other regimen.
