Research advances of hepcidin expression and its regulation mechanism.
- Author:
Chun-Kang CHANG
1
;
Xi ZHANG
;
Chao XIAO
;
Shu-Cheng GU
;
Xiao LI
Author Information
1. Department of Hematology, Shanghai Jiaotong University, Shanghai, China. changchunkang7010@yahoo.cn
- Publication Type:Journal Article
- MeSH:
Animals;
Antimicrobial Cationic Peptides;
metabolism;
Hepcidins;
Humans;
Membrane Proteins;
metabolism;
Signal Transduction
- From:
Journal of Experimental Hematology
2012;20(4):1030-1033
- CountryChina
- Language:Chinese
-
Abstract:
Hepcidin can regulate cell irons' efflux transport. The expression of hepcidin can be influenced by the body signals (such as serum ferritin and erythropoietin levels) as well as inflammation, hypoxia and other disease states. These stimulus activate the signaling pathway of BMP-the SMAD, the JAK-STAT and HIF1 through the liver parenchymal cell surface type I transmembrane glycoprotein of HFE, transferrin receptor 1, 2, hepcidin regulatory proteins, thereby changing the hepcidin gene transcription, regulating the expression levels of hepcidin. However, the molecular mechanism that regulate hepcidin expression is unclear. From the signal factors that affect hepcidin expression and signaling pathways involved in its expression, the latest research progress on regulatory mechanism of hepcidin are summarized.
