Expression of DNMT gene in bone marrow of patients with acute myelogenous leukemia and its significance.
- Author:
Sheng-Hao WU
1
;
Cui-Ping ZHENG
;
Jie XU
;
Xiao-Ping CAI
;
Yue-Jian SHI
Author Information
1. Department of Hematology, The Second People Hospital, Wenzhou, Zhejiang Province, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Bone Marrow;
metabolism;
pathology;
Case-Control Studies;
DNA (Cytosine-5-)-Methyltransferase 1;
DNA (Cytosine-5-)-Methyltransferases;
genetics;
metabolism;
Female;
Humans;
Karyotyping;
Leukemia, Myeloid, Acute;
genetics;
metabolism;
pathology;
Male;
Middle Aged;
Prognosis;
Young Adult
- From:
Journal of Experimental Hematology
2012;20(5):1063-1065
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to explore the expression and significance of DNMT1 gene in bone marrow of patients with acute myelogenous leukemia (AML). The expression of DNMT1 gene was detected by real-time PCR in 30 healthy people and 126 AML patients. The results showed that the expression level of DNMT1 gene was lower in the 30 healthy people and was higher in AML patients. There was a marked decline in the expression level of DNMT1 gene after complete remission (CR) as compared with the initial treatment. The expression level of DNMT1 gene did not correlated with age, sex and the clinical characteristics at initial diagnosis such as white blood cell count and chromosomal karyotype in AML patients. The CR rate in AML patients with low expression level of DNMT1 gene was lower than that in those with high expression level. It is concluded that bone marrow DNMT1 gene level may play an important role in AML pathogenesis and can serve as an index in evaluating AML prognosis.
