Research advance of hematopoietic microenvironment for myelodysplastic syndromes.
- Author:
Cheng-Ming FEI
1
;
Chun-Kang CHANG
Author Information
1. Department of Hematology, The 6th Hospital Affilated to Shanghai Jiaotong University, Shanghai, China.
- Publication Type:Journal Article
- MeSH:
Bone Marrow;
Cellular Microenvironment;
Cytokines;
metabolism;
Humans;
Myelodysplastic Syndromes;
Signal Transduction;
Stromal Cells;
metabolism
- From:
Journal of Experimental Hematology
2012;20(5):1246-1250
- CountryChina
- Language:Chinese
-
Abstract:
Myelodysplastic syndrome (MDS) is a group of heterogeneous clonal diseases characterized by ineffective hematopoiesis, peripheral blood cytopenias and high risk of transformation to acute myeloid leukemia.Recently more and more investigations indicate that the abnormality of bone marrow microenvironment is one of important reasons related to MDS. In this article the abnormality of stroma cells, cytokines and signaling pathways in hematopoietic micro-environment of MDS is reviewed.
