Research advances on correlation of ARID5B gene with childhood acute lymphoblastic leukemia - review.
- Author:
Xi-Feng QIAN
1
;
Guo-Hua YANG
;
Chen-Yu YIN
;
Xiang CHEN
;
Yun-Feng SHEN
Author Information
1. Department of Hematology, Nanjing Medical University, Wuxi, Jiangsu Province, China. qxf5828@sina.com
- Publication Type:Journal Article
- MeSH:
Child;
DNA-Binding Proteins;
genetics;
Humans;
Polymorphism, Single Nucleotide;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
genetics;
Transcription Factors;
genetics
- From:
Journal of Experimental Hematology
2012;20(5):1280-1283
- CountryChina
- Language:Chinese
-
Abstract:
Childhood acute lymphoblastic leukemia (C-ALL) is the most common pediatric cancer. Although its etiology remains poorly understood, the hypothesis of ALL correlated with a genetic basis was examined through association studies based on candidate genes. Recently, two independent large-scale genome-wide association studies reported that the five single nucleotide polymorphisms (rs7073837; rs10821936; rs10994982; rs7089424; rs10740055) in the gene AT rich interactive domain 5B (ARID5B) at 10q21.2, were associated with the high incidence risk of C-ALL, especially with hyperdiploid lymphoblastic leukemia. Variations in these single nucleotide polymorphisms influence the risk of specific disease subtypes, and also possess race- and sex-differences in leukemia incidence. Further elucidation of the mechanisms through which ARID5B variants are involved in C-ALL not only has a great diagnostic value, but also a guidance for the clinical therapy, ultimately improving the prognosis of disease. Therefore, the related studies of ARID5B with C-ALL were summarized briefly in this review.
