Reactive oxygen species and fibrosis in tissues and organs - review.
- Author:
Juan-Xia MENG
1
;
Ming-Feng ZHAO
Author Information
1. Department of Hematology and Oncology, Tianjin Medical University, Tianjin, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Bone Marrow;
pathology;
Bone Marrow Diseases;
metabolism;
pathology;
Fibrosis;
Humans;
Liver;
pathology;
Liver Cirrhosis;
metabolism;
pathology;
Lung;
pathology;
Pulmonary Fibrosis;
metabolism;
pathology;
Reactive Oxygen Species
- From:
Journal of Experimental Hematology
2012;20(5):1284-1288
- CountryChina
- Language:Chinese
-
Abstract:
Reactive oxygen species (ROS) is a kind of molecules derived by oxygen in the metabolic process of aerobic cells, which mainly includes superoxide, hydroxyl radicals, alkoxyl, hydrogen peroxide, hypochlorous acid, ozone, etc. They can destroy the structure and function of cells through the damage of biological macromolecules such as DNA, proteins and the lipid peroxidation. ROS also can regulate the proliferation, differentiation and apoptosis of cells through several signaling pathways and participate in fibrogenesis of many organs including hepatic and pulmonary fibrosis. Recent study shows that ROS might have an important effect on the forming of myelofibrosis. Consequently, ROS plays a significant role in the fibrogenesis of tissues and organs. In this review, the relevance between ROS and common tissues and organs fibrosis is summarized.
