Additional karyotypic abnormalities analysis in patients with hematological malignancies post-allogeneic hematopoietic stem cell transplantation.
- Author:
Jia-wei ZHAO
1
;
Wei-hua ZHAI
;
Cheng-wen LI
;
Qin ZHANG
;
Fang-yun XU
;
Heng-hua CHEN
;
Jin-ya YUE
;
Ming-zhe HAN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Female; Hematologic Neoplasms; genetics; surgery; Hematopoietic Stem Cell Transplantation; adverse effects; methods; Humans; Karyotyping; Male; Prognosis; Retrospective Studies; Young Adult
- From: Chinese Journal of Hematology 2012;33(8):619-622
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the karyotype stability in hematological malignancies patients before and after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and its prognostic significance of monitoring.
METHODSThe karyotypes and clinical data of 21 patients with hematological malignancies at the initial diagnosis and at relapse after allo-HSCT were retrospectively reviewed. Chromosome analysis was performed by standard 24 h-cultured method and R banding.
RESULTSKaryotypes at the initial diagnosis and at relapse after allo-HSCT were different in 11 patients (52.38%), including chromosome 1, 3, 6, 12, 17, 21. Numberical abnormalities and structural chromosomal abnormalities always occurs together. The median survival time of relapse of the patients with karyotype changes was significantly shorter than that of patients without a karyotype change (79 d vs 522 d, P = 0.027), and that of the patients with trisomy 6 was also significantly shorter than that of the patients without trisomy 6 (9 d vs 275 d, P = 0.005).
CONCLUSIONKaryotype changes after relapse are associated with the prognosis of allo-HSCT.
