Clinical and laboratory features of acute monocytic leukemia with B lymphoproliferative disorders.
- Author:
Xue-Jing CHEN
1
;
Yan LIU
;
Gui-Qing GUO
;
Qing-Nian CHENG
;
Bing-Cheng LIU
;
Dong LIN
;
Kai-Qi LIU
;
Ying-Chang MI
;
Jian-Xiang WANG
;
Hui-Jun WANG
Author Information
- Publication Type:Case Reports
- MeSH: Aged; B-Lymphocytes; pathology; Female; Humans; Leukemia, Monocytic, Acute; complications; diagnosis; pathology; Lymphocytosis; complications; diagnosis; pathology; Middle Aged
- From: Chinese Journal of Hematology 2012;33(9):710-714
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo identify the clinical and pathological features of acute myeloid leukemia with B lymphoproliferative disorders.
METHODSThe characteristics of 3 cases of acute monocytic leukemia with untreated chronic lymphocytic leukemia/monoclonal B-cell lymphocytosis were reported with literatures review.
RESULTSThe patients presented with a history of anemia, bleeding and/or fever. Acute monocytic leukemia was diagnosed by bone marrow morphology, cytochemistry and pathology studies. Immunophenotyping by flow cytometry analysis showed a significant population of absolute B-lymphocyte count of > 5×10(9)/L in a patients, similar to that of chronic lymphocytic leukemia.
CONCLUSIONSThe association of acute monocytic leukemia and untreated chronic lymphocytic leukemia/monoclonal B-cell lymphocytosis was a rare event. The abnormal B lymphocytes was likely to be misdiagnosis. Thus, it was important to combine several kinds of laboratory studies, especially flow cytometry to identify this rare disorder.
