Identification of a novel HLA-A allele A*11:01:37 by sequence-based typing.
- VernacularTitle:组织细胞肉瘤四例临床病理学分析
- Author:
Chun-Lai ZHANG
1
;
Gang LIANG
;
Yi ZHANG
;
Wen-Ben QIAO
;
Chuan-Fu ZHU
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; Base Sequence; Blood Donors; HLA-A11 Antigen; genetics; Humans; Sequence Analysis, DNA
- From: Chinese Journal of Hematology 2012;33(9):756-758
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo identify a novel HLA-A allele in a Chinese Han individual.
METHODSOne mismatch was observed in HLA-A locus in HLA typing for CMDP donors using bi-allelic SBT kit. A confirmatory test for novel HLA allele was performed with mono-allelic SBT kit.
RESULTSThe DNA sequence was confirmed to be a novel HLA-A allele. There was 1 nucleotide differed from the closest matching HLA-A*11:01:01 at position 393(G→A), which resulting a change from GGG to GGA at codon 107, led to a silent mutation, conserving the amino acid Gly.
CONCLUSIONA novel HLA-A allele was confirmed and officially named HLA-A*11:01:37 (Genbank accession number, JN209962) by the WHO Nomenclature Committee for Factors of the HLA System in January 2012.
