Hepatobiliary transport of glutathione and its role in cholestasis.
- Author:
Xue-ying ZHANG
1
;
Jin YANG
;
Xue-fen YIN
;
Xiao-dong LIU
;
Guang-ji WANG
Author Information
1. Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Biological Transport;
Cholestasis;
chemically induced;
metabolism;
prevention & control;
Estrogens;
adverse effects;
Glutathione;
metabolism;
Humans;
Jaundice, Chronic Idiopathic;
genetics;
Liver;
metabolism;
Multidrug Resistance-Associated Proteins;
genetics;
metabolism;
Mutation;
Phalloidine;
adverse effects;
Ursodeoxycholic Acid;
therapeutic use
- From:
Acta Pharmaceutica Sinica
2009;44(4):327-332
- CountryChina
- Language:Chinese
-
Abstract:
Glutathione is a tripeptide comprised by L-glutamate, L-cysteine, and glycine, that serves antioxygenation and deintoxication functions within the cell. Recent study has found that glutathione is the main driving force for bile salt-independent bile flow, impaired biliary excretion of glutathione can lead to cholestasis. This review focuses on hepatobiliary transport of glutathione and its role in cholestasis. Based on the evidence of choleretic effect of glutathione, enhancement of biliary excretion of glutathione may be a good strategy for prevention and treatment of cholestasis.
