Synthesis, solubility, lipids-lowering and liver-protection activities of sulfonated formononetin.
- Author:
Qiu-ya WANG
1
;
Qing-hua MENG
;
Zun-ting ZHANG
;
Zhen-jun TIAN
;
Hui LIU
Author Information
1. Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an 710062, China.
- Publication Type:Journal Article
- MeSH:
Adipose Tissue;
drug effects;
Alanine Transaminase;
metabolism;
Animals;
Aspartate Aminotransferases;
metabolism;
Cholesterol;
blood;
Cholesterol, HDL;
blood;
Cholesterol, LDL;
blood;
Hypolipidemic Agents;
chemical synthesis;
chemistry;
pharmacology;
Isoflavones;
chemical synthesis;
chemistry;
pharmacology;
Lipids;
blood;
Liver;
enzymology;
pathology;
Male;
Molecular Structure;
Protective Agents;
chemical synthesis;
chemistry;
pharmacology;
Rats;
Rats, Sprague-Dawley;
Solubility;
Triglycerides;
blood
- From:
Acta Pharmaceutica Sinica
2009;44(4):386-389
- CountryChina
- Language:Chinese
-
Abstract:
A water-soluble compound, sodium formononetin-3'-sulfonate with good lipid-lowering and liver-protection activities was synthesized. It was synthesized by sulfonation reaction, and its structure was characterized by IR, NMR and elemental analyses. The solubility of sodium formononetin-3'-sulfonate in water and n-octanol/water partition coefficient were determined by UV spectrophotometry. The lipid-lowering and liver-protection activities of sodium formononetin-3'-sulfonate were tested by using rat's high fat model induce by feeding with high fat food. The results showed that sodium formononetin-3'-sulfonate not only had favorable water, solubility but also had good lipid-lowering and liver-protection activities.
