Isolation and characterization of xanthine oxidase inhibitory constituents of Pyrenacantha staudtii.
- Author:
Abiodun FALODUN
1
;
Muhammad Irfan QADIR
;
Muhammad Iqbal CHOULDARY
Author Information
1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria. faloabi25@yahoo.com
- Publication Type:Journal Article
- MeSH:
Enzyme Inhibitors;
chemistry;
isolation & purification;
pharmacology;
Glucosides;
chemistry;
isolation & purification;
pharmacology;
Kaempferols;
chemistry;
isolation & purification;
pharmacology;
Magnoliopsida;
chemistry;
Molecular Structure;
Niacin;
chemistry;
isolation & purification;
pharmacology;
Plant Leaves;
chemistry;
Plants, Medicinal;
chemistry;
Xanthine Oxidase;
metabolism
- From:
Acta Pharmaceutica Sinica
2009;44(4):390-394
- CountryChina
- Language:English
-
Abstract:
Six compounds have been isolated from the leaves of Pyrenacantha staudtii, two of which are new compounds. The new compounds have been characterized as kaempherol 3-O-beta-rhamnopyranosyl (1-->6)-beta-D-glucopyranoside (1) and 4-beta-glucopyranosyl-(2-furyl)-5-methy-1,2-glucopyranoside phenylmethanone (2). The known compounds are 3-pyridinecarboxylic acid (3), beta-sitosterol (4), sitosterol 3-O-beta-glucopyranoside (5) and taraxerol (6). Their structures were determined by spectroscopic and chemical evidences. The two new compounds together with 3-pyridinecarboxylic acid showed significant in vitro xanthine oxidase inhibitory activity. To the best of our knowledge, this is the first report of these compounds from this plant.
