Preliminary exploration of inhibitory activities of Salvia species on PTP1B.
- Author:
Xin-xin HU
1
;
Yan-fang YANG
;
Ying-tao ZHANG
Author Information
1. School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
- Publication Type:Journal Article
- MeSH:
Chromatography, High Pressure Liquid;
Drugs, Chinese Herbal;
isolation & purification;
pharmacology;
Enzyme Inhibitors;
isolation & purification;
pharmacology;
Humans;
Plant Roots;
chemistry;
Plants, Medicinal;
chemistry;
Protein Tyrosine Phosphatase, Non-Receptor Type 1;
antagonists & inhibitors;
Salvia;
chemistry;
classification
- From:
Acta Pharmaceutica Sinica
2009;44(4):440-442
- CountryChina
- Language:Chinese
-
Abstract:
An in vitro screening model was applied to test the inhibitory activities of 17 Salvia species on protein tyrosine phosphatase 1B (PTP1B). Root methanol extracts from wild-collected Salvia species were analyzed using this model. Most of the samples tested showed positive activities on human PTP1B. The inhibition rates of Salvia crude extracts varied from 9.76% to 100% at 30 microg x mL(-1), with the most convincing effects coming from Salvia evansiana and Salvia castanea. HPLC analysis revealed seven components shared by Salvia samples could be related to the inhibitory activities.