Therapeutic effect of astaxanthin on acetic acid-induced gastric ulcer in rats.
- Author:
Qiong YANG
1
;
Zhen ZHANG
;
Xuan ZHU
;
Hang RUAN
;
Yan FU
Author Information
1. School of Pharmacy, Yanbian University, Yanji 133000, China.
- Publication Type:Journal Article
- MeSH:
Acetic Acid;
Animals;
Anti-Ulcer Agents;
therapeutic use;
Antioxidants;
therapeutic use;
Catalase;
metabolism;
Gastric Mucosa;
metabolism;
pathology;
Glutathione Peroxidase;
metabolism;
Male;
Malondialdehyde;
metabolism;
Random Allocation;
Rats;
Rats, Sprague-Dawley;
Stomach Ulcer;
chemically induced;
drug therapy;
metabolism;
pathology;
Superoxide Dismutase;
metabolism;
Xanthophylls;
therapeutic use
- From:
Acta Pharmaceutica Sinica
2009;44(5):558-560
- CountryChina
- Language:Chinese
-
Abstract:
This study is to investigate therapeutic effect of astaxanthin on acetic acid-induced gastric ulcer in rats. Rats were divided into control group, ulcer control group, and astaxanthin (5, 10, and 25 mg x kg(-1)) groups at random, 8 rats in each group. After administered for 10 days consecutively, all the rats were sacrificed. The area of ulcer and the levels of MDA, SOD, CAT and GSH-Px in gastric mucosa were measured. Compared with ulcer control group, in astaxanthin (5, 10, and 25 mg x kg(-1)) groups, the area of ulcer was decreased significantly. Level of MDA decreased while activities of SOD, CAT and GSH-Px increased (P < 0.05). Astaxanthin has good therapeutic effect on acetic acid-induced gastric ulcer in rats. Eliminating free radical and improving local blood circulation of the ulcer may be the mechanism of action.
