Antifungal active triterpene glycosides from sea cucumber Holothuria scabra.
- Author:
Hua HAN
1
;
Yang-Hua YI
;
Ling LI
;
Bao-Shu LIU
;
Ming-Ping LA
;
Hong-Wei ZHANG
Author Information
1. Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Antifungal Agents;
isolation & purification;
pharmacology;
Glycosides;
chemistry;
isolation & purification;
pharmacology;
Holothuria;
chemistry;
Holothurin;
analogs & derivatives;
chemistry;
isolation & purification;
pharmacology;
Molecular Structure;
Triterpenes;
chemistry;
isolation & purification;
pharmacology
- From:
Acta Pharmaceutica Sinica
2009;44(6):620-624
- CountryChina
- Language:English
-
Abstract:
To study the new antifungal active triterpene glycosides of sea cucumber Holothuria scabra. Triterpene glycosides from Holothuria scabra were separated and purified by silica gel chromatography, reversed-phase silica gel chromatography and RP-HPLC. Their structures were elucidated on the basis of spectral data and chemical evidence. Three triterpene glycosides were identified as scabraside A (1), echinoidea A (2) and holothurin A1 (3). Scabraside A (1) is a new triterpene glycoside, and compounds 2 and 3 were isolated from Holothuria scabra for the first time. They showed antifungal activities (1 < or = MIC80 < or = 16 microg mL(-1)).
