Recent advances in the study of bioreductive drugs targeted tumor hypoxia.
- Author:
Jing-Bao LIU
1
;
Lei FU
;
Yong-Zhou HU
;
Fa-Qin JIANG
Author Information
1. Department of Medicinal Chemistry, College of Pharmaceutical Sciences, Shanghai Jiaotong University, Shanghai 200240, China.
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents;
therapeutic use;
Cell Hypoxia;
Humans;
Hypoxia;
Neoplasms;
drug therapy;
Quinones;
therapeutic use;
Reducing Agents;
therapeutic use
- From:
Acta Pharmaceutica Sinica
2009;44(7):695-702
- CountryChina
- Language:Chinese
-
Abstract:
Tumor hypoxia is the necessary process in the development of solid tumors, which is the key factor for drug resistance, recurrence, attack and shift of tumor. Hypoxic tumor cells have a certain extent of tolerance to radiation and chemotherapy. Tumor hypoxia is an important target for medication therapy. In the recent years, the bioreductive drugs targeted tumor hypoxia has made great process in the treatment of tumors. The latest advances of bioreductive drugs targeted hypoxia were reviewed in this paper.
