Progress in the study of micelle delivery system reversing multidrug resistance.
- Author:
Yuan-Yuan DIAO
1
;
Min HAN
;
Da-Wei CHEN
;
Jian-Qing GAO
Author Information
1. Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Zhejiang 310058, China.
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents;
administration & dosage;
pharmacology;
Drug Delivery Systems;
Drug Resistance, Multiple;
drug effects;
Drug Resistance, Neoplasm;
drug effects;
Micelles;
Nanoparticles
- From:
Acta Pharmaceutica Sinica
2009;44(7):710-715
- CountryChina
- Language:Chinese
-
Abstract:
Multidrug resistance (MDR) of cancer cells to anti-tumor drugs remains a major impediment to successful chemotherapy. There has been an increasing interest in the studies of the mechanism and reverse of the MDR. Being a reliable and safe way to reverse MDR, drug delivery systems (DDS) such as micelle, liposome and nanoparticle, represent a promising prospect both in research and application in recent years. On the basis of recent studies, the effect and mechanism of micelles on reversing MDR are reviewed. And it is anticipated that DDS could contribute greatly to reversing MDR in the future.
