Design and synthesis of 3'-methyl-furanonucleosides and their anti-tumor activities.
- Author:
Li-Hong SHI
1
;
Dong-Zhe JIN
;
Wei-Cheng ZHOU
;
Juan WANG
;
Xiu-Hua CHEN
Author Information
1. State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, Shanghai 200437, China. shilihong6@hotmail.com
- Publication Type:Journal Article
- MeSH:
Adenosine;
analogs & derivatives;
chemical synthesis;
pharmacology;
Antineoplastic Agents;
chemical synthesis;
pharmacology;
Cell Line, Tumor;
Cladribine;
chemical synthesis;
pharmacology;
Drug Screening Assays, Antitumor;
Humans;
Molecular Structure
- From:
Acta Pharmaceutica Sinica
2009;44(7):747-753
- CountryChina
- Language:Chinese
-
Abstract:
Taking 3'-Me-Ado (3'-methyladenosine) and Cladribine as the leading compounds, seventeen 3'-C-methyl-furanonucleosides were designed and synthesized. All the structures were confirmed by 1H NMR and MS. The target compounds were tested in vitro against human pulmonary carcinoma A549, human colon carcinoma LOVO and human leukemia CEM by MTT assay. The results showed that these compounds possessed moderate cytotoxicities.
