Serum levels of macrophage colony stimulating factor in the patients with Alzheimer's disease.
- Author:
Qing-li KONG
1
;
Jian-min ZHANG
;
Zhen-xin ZHANG
;
Ping-jiang GE
;
Ya-jun XU
;
Ru-shun MI
;
Yu-hua ZHAO
;
Yan-ping SUI
;
Wei HE
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Alzheimer Disease; blood; Biomarkers; blood; Female; Humans; Interleukin-1; blood; Interleukin-6; blood; Macrophage Colony-Stimulating Factor; blood; Male; Middle Aged; Tumor Necrosis Factor-alpha; metabolism
- From: Acta Academiae Medicinae Sinicae 2002;24(3):298-301
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the availability of serum level of macrophage clony stimulating factor (M-CSF) as a marker for early diagnosis of Alzheimer's disease (AD).
METHODSThe serum levels of M-CSF in 70 patients with AD, 52 healthy controls, 22 patients with VAD (vascular dementia) were measured and the serum levels of IL-1 beta, IL-6, TNF-alpha in 32 patients with AD and 20 controls were measured as well.
RESULTSSerum levels of M-CSF were significantly elevated in patients with AD when compared with healthy controls (P < 0.01) and VAD controls (P < 0.05) respectively. At the early stage of mild dementia and middle dementia, serum levels of M-CSF were significantly elevated, but at the later stage of severe dementia, they returned to normal level. Serum levels of IL-1 beta were significantly elevated in AD patients compared with controls (P < 0.05), and serum levels of TNF-alpha and IL-6 were within the normal range in patients with AD.
CONCLUSIONSThe results suggest that serum M-CSF level may provide a convenient and sensitive means for the early diagnosis of Alzheimer's disease.
