Synthesis and preliminary studies of O-(2-18F fluoroethyl)-L-tyrosine as a positron emission tomography imaging agent.
- Author:
Yong-hong DANG
1
;
Shi-zhen WANG
;
Xin CHENG
;
Qian ZHOU
Author Information
- Publication Type:Case Reports
- MeSH: Adult; Animals; Brain Neoplasms; diagnostic imaging; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Glioblastoma; diagnostic imaging; Humans; Male; Mice; Middle Aged; Sarcoma 180; diagnostic imaging; Tomography, Emission-Computed; Tyrosine; analogs & derivatives; chemical synthesis
- From: Acta Academiae Medicinae Sinicae 2002;24(4):370-372
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo develop a 18F-labeled amino acid, O-(2-[18F]fluoroethyl) - L-tyrosine(18F-FET), as a positron emission tomography (PET) tracer for imaging cerebral tumors.
METHODS18F-FET was synthesized. Preclinical studies including sterility, endotoxin, and toxicity tests were performed. Two brain tumor cases were studied using 18F-FET and compared with 18F-FDG.
RESULTSRadiochemical purity of 18F-FET was over 95% which remained stable for 6 hours. The 18F-FET injection was sterile and its endotoxin content accorded with the standards of Chinese Pharmacopoeia. The uptake of 18F-FET in the normal brain tissues was significantly lower than that of the tumor, and the images of the brain tumor were clearer than those of 18F-FDG.
CONCLUSION18F-FET can accumulate in the tumor tissues to give high quality images. It suggests that 18F-FET may be a safe and effective tracer for brain tumor imaging.
