Toll-like receptor and innate immunity in phylogenesis.
- Author:
Ye LIU
1
;
Li-ping ZHU
;
Wei HE
Author Information
1. Department of Clinical Medicine, PUMC, Beijing 100730, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Humans;
Immunity;
Membrane Glycoproteins;
immunology;
Phylogeny;
Receptors, Cell Surface;
immunology;
Toll-Like Receptors
- From:
Acta Academiae Medicinae Sinicae
2002;24(4):433-436
- CountryChina
- Language:Chinese
-
Abstract:
In protection against microbes, an organism recognizes the pathogen associated molecular pattern (PAMP) on microbes by pattern recognition receptor (PRR). Toll-like receptor is called innate immunity. A family of cell membrane receptor was found in recent years that can mediate innate immune responses through the activation of a series of immune-related genes. In phylogenesis, it is highly conservative. However, its functions are getting more diversified with the complication of the immune functions of organisms.
