B cell activated co-receptor.
- Author:
Xia RUAN
1
;
Li-ping ZHU
;
Wei ZHANG
Author Information
1. Department of Clinical Medicine, PUMC, Beijing 100730, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Antigens, CD19;
immunology;
Autoantigens;
immunology;
B-Lymphocytes;
immunology;
Humans;
Receptors, Complement 3d;
immunology;
Receptors, Immunologic
- From:
Acta Academiae Medicinae Sinicae
2002;24(4):436-439
- CountryChina
- Language:Chinese
-
Abstract:
B cell activated co-receptor plays important roles in linkage of innate and acquired humoral immune responses. CD21 molecule in the co-receptor complex is a receptor for C3dg and CD19 molecule enhances BCR signal transduction. CD21 also expresses on the surface of follicular dendritic cells, which mediates the long-term maintenance of antigens and is indispensable for maintaining the memory of B cells. B cell activated co-receptor also has an effect on the negative selection of B cells reactive to autoantigens.
