Cytotoxic T cell.
- Author:
Ge MA
1
;
Li-ping ZHU
;
Wei ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Fas Ligand Protein; Humans; Membrane Glycoproteins; immunology; Perforin; Pore Forming Cytotoxic Proteins; T-Lymphocytes, Cytotoxic; immunology; fas Receptor; immunology
- From: Acta Academiae Medicinae Sinicae 2002;24(4):439-442
- CountryChina
- Language:Chinese
- Abstract: Cytotoxic T cell (CTL) covers several subtypes, which are CD8+, CD4 and CD4-CD8-. CTL derives from T cell repertoire in lymphoid hematopoietic stem cells. It matures in thymus and is activated in peripheral lymphoid tissues. Effector CTL kills the target cells by 2 ways. One is apoptotic effect mediated by FasL-Fas pathway and the other one is cytolytic effect mediated by granzymes. CTL has aroused great attention due to its significance in anti-tumor and anti-virus.
