Intra-arterial thrombolysis in patients with acute ischemic stroke of the cervical internal carotid artery occlusive disease.
- Author:
Qing ZHANG
1
;
Zheng-yu JIN
;
Yi-ning HUANG
;
Wei-hai XU
;
Zu-yuan REN
;
Chang-bao SU
;
Ren-zhi WANG
;
Wei LIU
;
Jie PAN
;
Li-ying CUI
;
Shan GAO
;
Jian YE
;
Jian-ping DAI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Carotid Artery, Internal; Carotid Stenosis; complications; drug therapy; Female; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Stroke; drug therapy; etiology; Thrombolytic Therapy; methods; Urokinase-Type Plasminogen Activator; administration & dosage
- From: Acta Academiae Medicinae Sinicae 2002;24(6):646-649
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the safety and efficacy of local intra-arterial thrombolysis (LIT) in patients with acute ischemic stroke of cervical internal carotid artery occlusive disease.
METHODS10 patients were treated by LIT. 2 of 10 patients were further treated by either angioplasty or endarterectomy. Primary neuroradiological assessment was performed with CT in all patients. Angiographic recanalization level was classified according to thrombolysis in myocardial infarction (TIMI) grades. Clinical outcome was classified as good for Modified Rankin Scale (MRS) scores of 0 to 3 and as poor for MRS scores of 4 to 6.
RESULTSComplete/partial recanalization after infusion was accomplished in 8 patients, seven of whom had good clinical outcome. Cerebral hemorrhage occurred in 2 of 10 patients.
CONCLUSIONThe results of this study suggest that LIT may be helpful to improve the outcome in patients with acute cervical internal carotid artery occlusive disease if it is performed within 6 hours of stroke onset.
