Correlation analysis between WNK4 gene and essential hypertension.
- Author:
Zhi-jun SUN
1
;
Xin-nan WANG
;
Jing-yu LU
;
Qian DING
;
Ling-yue DONG
;
Yan-yan ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Brain; metabolism; Female; Gene Expression; Gene Frequency; Genes; Genetic Predisposition to Disease; Humans; Hypertension; genetics; Kidney; metabolism; Lysine; genetics; Male; Middle Aged; Mutation; Phenotype; Protein-Serine-Threonine Kinases; biosynthesis; genetics; RNA, Messenger; biosynthesis; genetics
- From: Acta Academiae Medicinae Sinicae 2003;25(2):145-148
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate association of mutation in WNK4 gene with essential hypertension and to analyze the expression of WNK4 gene.
METHODScSNP in WNK4 gene in a small samples was detected by sequencing, then PCR-RFLP was performed in 98 patients with essential hypertension and 95 control subjects. The expression profile of WNK4 gene was tested by RT-PCR.
RESULTSA cSNP was detected in WNK4 gene exon7 G1662A, and there were significant differences in the distribution of allele frequency of G1662A between essential hypertension group and control group. WNK4 gene were expressed in the tissues of kidney, brain, lung, heart, spleen and intestine of fetus.
CONCLUSIONWNK4 gene is well correlated with essential hypertension.
