Role of Ski/SnoN protein in the regulation of TGF-beta signal pathway.
- Author:
Zhao-hui LU
1
;
Jie CHEN
Author Information
1. Department of Pathology, PUMC Hospital, CAMS, PUMC, Beijing 100730, China.
- Publication Type:Journal Article
- MeSH:
Animals;
DNA-Binding Proteins;
metabolism;
physiology;
Humans;
Intracellular Signaling Peptides and Proteins;
Proto-Oncogene Proteins;
physiology;
Signal Transduction;
Smad3 Protein;
Smad4 Protein;
Trans-Activators;
metabolism;
Transcription, Genetic;
Transforming Growth Factor beta;
physiology
- From:
Acta Academiae Medicinae Sinicae
2003;25(2):233-236
- CountryChina
- Language:Chinese
-
Abstract:
TGF-beta signal pathway plays an important role in the cell growth, differentiation, formation of extracellular matrix, embryo development and carcinogenesis, etc. However, the regulation of TGF-beta pathway is not totally understood. In 1999, three independent research groups found that Ski/SnoN protein could inhibit the TGF-beta mediated transcription by recruiting N-CoR, a transcription co-repressor. Later studies suggested that TGF-beta and SMADs degraded the Ski/SnoN protein by mediating ubiquitin linkage, showing negative feedback regulation. The important findings in Ski/SnoN laid the theoretical foundation for demonstrating the function of TGF-beta signal pathway.
