Effect of jianpi wenshen decoction on serum gastrin, plasma motilin and somatostatin in patients of diabetic diarrhea.
- Author:
Wen XIAO
1
;
Jing LIU
;
Li-ying LIU
Author Information
- Publication Type:Clinical Trial
- MeSH: Adult; Aged; Diabetes Mellitus, Type 1; complications; Diabetes Mellitus, Type 2; blood; complications; drug therapy; Diarrhea; blood; drug therapy; etiology; Drugs, Chinese Herbal; therapeutic use; Female; Gastrins; blood; Humans; Male; Middle Aged; Motilin; blood; Phytotherapy; Somatostatin; blood
- From: Chinese Journal of Integrated Traditional and Western Medicine 2002;22(8):587-589
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of Jianpi Wenshen Decoction (JWD) on serum gastrin, plasma motilin and somatostatin in patients of diabetic diarrhea (DD).
METHODSPatients with DD were randomly divided into two groups, the JWD group and the control group treated with Loperamide (LPA). Besides, a normal control group was set up. Changes of serum gastrin, plasma motilin and somatostatin were observed.
RESULTSBefore treatment, the levels of gastrin and motilin in both groups were higher and somatostatin lower than those in the normal control group. After 1 month treatment, levels of the three indices were restored in both group approaching the normal range with insignificance as compared with those in the normal control group (P > 0.05). Level of plasma motilin and serum gastrin showed an increasing trend along with the therapeutic effect elevation, while level of somatostatin showed a decreasing trend.
CONCLUSIONJWD could promote the recovery of the impaired function of vegetative nerve system in DD patients. At the same time, serum gastrin, plasma motilin and somatostatin may be taken as the indexes for evaluating the efficacy in treating DD.
