Spatiotemporal Analysis of Retinal Waveform using Independent Component Analysis in Normal and rd/rd Mouse.
- Author:
Jang Hee YE
1
;
Tae Seong KIM
;
Yong Sook GOO
Author Information
1. Department of Physiology, Chungbuk National University School of Medicine, Chungju, Korea. ysgoo@chungbuk.ac.kr
- Publication Type:Original Article
- Keywords:
Degenerate retina;
Multielectrode array;
Principal component analysis;
Independent component analysis;
Retinal waveform
- MeSH:
Animals;
Ganglion Cysts;
Mice*;
Passive Cutaneous Anaphylaxis;
Principal Component Analysis;
Retina;
Retinaldehyde*;
Spatio-Temporal Analysis*
- From:Korean Journal of Medical Physics
2007;18(1):20-26
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
It is expected that synaptic construction and electrical characteristics in degenerate retina might be different from those in normal retina. Therefore, we analyzed the retinal waveform recorded with multielectrode array in normal and degenerate retina using principal component analysis (PCA) and independent component analysis (ICA) and compared the results. PCA is a well established method for retinal waveform while ICA has not tried for retinal waveform analysis. We programmed ICA toolbox for spatiotemporal analysis of retinal waveform. In normal mouse, the MEA spatial map shows a single hot spot perfectly matched with PCA-derived ON or OFF ganglion cell response. However in rd/rd mouse, the MEA spatial map shows numerous hot and cold spots whose underlying interactions and mechanisms need further investigation for better understanding.
