Research Advances in Pituitary Adenoma and DNA Methylation.
10.3881/j.issn.1000-503X.2016.04.019
- Author:
Zhen-Qing WEI
1
;
Yang LI
1
;
Wei-Hua LI
1
;
Jia-Cheng LOU
2
;
Bo ZHANG
2
Author Information
1. Department of Neurosurgery,the First Hospital Affiliated to Dalian Medical University,Dalian,Liaoning 116011,China.
2. Department of Neurosurgery,the Second Hospital Affiliated to Dalian Medical University,Dalian,Liaoning 116000,China.
- Publication Type:Journal Article
- MeSH:
Adenoma;
genetics;
DNA Methylation;
Gene Expression Regulation, Neoplastic;
Humans;
Pituitary Neoplasms;
genetics;
Promoter Regions, Genetic
- From:
Acta Academiae Medicinae Sinicae
2016;38(4):475-479
- CountryChina
- Language:English
-
Abstract:
DNA methylation is closely related to the genesis and development of pituitary adenoma. Studies have shown that high methylation in the promoter region of potassium voltage-gated chanel,shaker related subfamily,beta member 2,O-6-methylguanine-DNA methyltransferase,echinoderm microtubule associated protein like 2 ,ras homolog family member D ,homeobox B1 ,NNAT, and P16 inhibits the expression of these genes and regulates of the proliferation of pituitary adenoma. DNA methylation is also closely related to invasive pituitary adenoma. Therefore,further study on molecular mechanism of DNA methylation of pituitary adenoma will offer a new strategy for the diagnosis and treatment of pituitary adenoma.
