Clinical Features of Pituitary Stalk Interruption Syndrome in 114 Cases.
- Author:
Bai-Yu HAN
1
,
2
;
Qian ZHANG
1
;
Le-Le LI
3
;
Qing-Hua GUO
3
;
Cheng-Zhi WANG
3
;
Li CANG
3
;
Nan JIN
3
;
Fang CHEN
3
;
Ling ZHAO
3
;
Jia CUI
3
;
Xiu-Lian GU
3
;
Fang-Ling MA
3
;
Sai-Chun ZHANG
3
;
Yi-Ming MU
3
;
Jing-Tao DOU
3
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Dwarfism; etiology; Female; Humans; Magnetic Resonance Imaging; Male; Pituitary Diseases; complications; physiopathology; Pituitary Gland; pathology; Prevalence; Retrospective Studies; Young Adult
- From: Acta Academiae Medicinae Sinicae 2016;38(5):534-538
- CountryChina
- Language:English
- Abstract: Objective To analyze the clinical characteristics of pituitary stalk interruption syndrome(PSIS). Methods The clinical data including clinical manifestations,laboratory tests,and imaging findings of 114 PSIS patients in our hospital were retrospectively analyzed. Results Of these 114 PSIS patients,102 cases (89.4%) were male. The average age was 21.1?6.1 years. A history of breech delivery was documented in 91 cases (91.9%). Short stature was found in 89 cases (71.8%) and bone age delayed (6.1?5.1) years. Secondary sex characteristics were poor or undeveloped in most patients. The prevalence of deficiencies in growth hormone,gonadotropins,corticotropin,and thyrotropin were 100.0%,94.0%,84.2%,and 74.6%,respectively. Hyperprolactinemia was found in 28.1% of patients. Three or more pituitary hormone abnormalities were found in 105 cases(92.1%). Compared with the 5 cases with history of cephalic delivery,no difference were found in the aspects of height(t=0.297,P=0.634),penile length(t=1.205,P=0.882),testicular volume (U=99.000,P=0.348),growth hormone peak (U=89.000,P=0.186),adrenocorticotropic hormone peak(U=131.000,P=0.967),luteinizing hormone peak(U=98.500,P=0.582),thyroid-stimulating hormone (U=82.000,P=0.162),and the height of anterior pituitary (t=1.676,P=0.107) in the 53 cases with history of breech delivery. Conclusions The clinical manifestations,symptoms,hormone deficiencies were severe in our series. The condition severities were not remarkably different in patients with different delivery ways.
