Biological Characteristics of Cluster of Differentiation 147 and Its Relationship with Tumour.
10.3881/j.issn.1000-503X.2016.05.018
- Author:
Cen GAO
1
;
Chao-Hui LU
1
;
Jie CHEN
1
Author Information
1. Department of Pathology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
- Publication Type:Journal Article
- MeSH:
Basigin;
metabolism;
Fibroblasts;
Humans;
Neoplasms;
metabolism;
Neovascularization, Pathologic
- From:
Acta Academiae Medicinae Sinicae
2016;38(5):589-593
- CountryChina
- Language:English
-
Abstract:
Cluster of differentiation 147(CD147)/extracellular matrix metalloproteinase inducer (EMMPRIN) is a widely distributed transmembrane glycoprotein that belongs to the immunoglobulin superfamily and is highly enriched on the surface of malignant tumour cells. A major function of CD147 is to stimulate matrix metalloproteinase production in stromal fibroblasts and endothelial cells. CD147 promotes growth,invasion,metastasis,and glycolysis of malignant cells,induces angiogenesis,multidrug resistance,and anoikis resistance,and inhibits starvation-induced autophagy et al. This review focuses on the structural and biological characteristics of CD147 as well as recent advances in its multiple functions in malignant tumours and underlining mechanisms.
