Advances in the Relationship between Adipokines and β-cell Failure in Type 2 Diabetes Mellitus.
10.3881/j.issn.1000-503X.2016.05.020
- Author:
Qing SUN
1
;
Xiao-Chun LIANG
1
Author Information
1. Department of Traditional Chinese Medicine,PUMC Hospital, CAMS and PUMC,Beijing 100730,China.
- Publication Type:Journal Article
- MeSH:
Adipokines;
metabolism;
Adiponectin;
metabolism;
Diabetes Mellitus, Type 2;
physiopathology;
Humans;
Insulin Resistance;
Insulin-Secreting Cells;
pathology;
Leptin;
metabolism;
Obesity;
Resistin;
metabolism
- From:
Acta Academiae Medicinae Sinicae
2016;38(5):601-606
- CountryChina
- Language:English
-
Abstract:
β-cell failure coupled with insulin resistance plays a key role in the development of type 2 diabetes mellitus (T2DM). Changed adipokines in circulating level form a remarkable link between obesity and both β-cell failure and insulin resistance. Some adipokines have beneficial effects,whereas others have detrimental properties. The overall contribution of adipokines to β-cell failure mainly depends on the interactions among adipokines. This article reviews the role of individual adipokines such as leptin,adiponectin,and resistin in the function,proliferation,death,and failure of β-cells. Future studies focusing on the combined effects of adipokines on β-cells failure may provide new insights in the treatment of T2DM.
