Expressions of CD44,CD47,and c-met in Ovarian Clear Cell Carcinoma and Their Clinical Significance.
10.3881/j.issn.1000-503X.2016.06.016
- Author:
Hui-Min WANG
1
;
Ming-Zi TAN
1
;
Song ZHANG
2
;
Xiao LI
1
;
Jian GAO
1
;
Dan-Ye ZHANG
1
;
Ying-Ying HAO
1
;
Song GAO
1
;
Juan-Juan LIU
1
;
Bei LIN
1
Author Information
1. Department of Obstetrics and Gynecology,Shengjing Hospital Affiliated to China Medical University,Shenyang 110004,China.
2. Department of Obstetrics and Gynecology,Shengjing Hospital Affiliated to China Medical University,Shenyang 110004,China
- Publication Type:Journal Article
- MeSH:
Adenocarcinoma, Clear Cell;
metabolism;
CD47 Antigen;
metabolism;
Female;
Humans;
Hyaluronan Receptors;
metabolism;
Lymphatic Metastasis;
Ovarian Neoplasms;
metabolism;
Prognosis;
Proto-Oncogene Proteins c-met;
metabolism;
Survival Analysis
- From:
Acta Academiae Medicinae Sinicae
2016;38(6):720-725
- CountryChina
- Language:English
-
Abstract:
Objective To investigate the expressions of CD44,CD47,and c-met in ovarian clear cell carcinoma (OCCC) tissue and their correlations with clinical variables and prognosis. Methods Immunohistochemical method was used to investigate the expressions of CD44,CD47,and c-met in tissues from 86 OCCC patients and the relationships of their expressions with the clinicopathological factors of OCCC were analyzed. Results The expressions of CD44,CD47,and c-met were significantly high in OCCC tissues (90.7%,91.9%,and 94.2%,respectively). The strong positive expressions of CD44 and CD47 were significantly correlated with advanced International Federation of Gynecology and Obstetrics stages,chemotherapeutic resistance,and poor prognosis (all P<0.05),the strong positive expression of c-met was significantly correlated with chemotherapeutic resistance and poor prognosis (all P<0.05),whereas there was no correlation between the strong positive expressions of CD44,CD47,and c-met and the lymphatic node metastasis. COX survival analysis revealed that advanced International Federation of Gynecology and Obstetrics stages and high expressions of CD44,CD47 and c-met were independent risk factors for poor prognosis (P<0.05). There was a positive correlation between CD44 (or CD47) and c-met and between CD44 and CD47 (the Spearman correlation coefficient rwas 0.783,0.776,and 0.835,respectively,all P<0.01). Conclusions The expressions of CD44,CD47,and c-met increase in OCCC tissues and are correlated with each other. High expressions of CD44,CD47,and c-met are independent factors for poor prognosis.
