Research Advances in Chemokine-like Factor Super Family Member 8.
10.3881/j.issn.1000-503X.2016.06.021
- VernacularTitle:趋化素样因子超家族8研究进展
- Author:
Deng-Hui GAO
1
;
Hao HU
1
;
Zhi-Wei FANG
1
;
Fei HUO
1
;
Huan-Rui WANG
1
;
Ke-Xin XU
1
;
Xiao-Feng WANG
1
Author Information
1. Department of Urology,Peking University People's Hospital,Beijing 100044,China.
- Publication Type:Journal Article
- MeSH:
Chemokines;
metabolism;
Down-Regulation;
Humans;
MARVEL Domain-Containing Proteins;
metabolism;
Neoplasms;
metabolism;
Signal Transduction
- From:
Acta Academiae Medicinae Sinicae
2016;38(6):746-749
- CountryChina
- Language:English
-
Abstract:
Chemokine-like factor super family member (CMTM) is a novel generic family firstly reported by Peking University Center for Human Disease Genomics. CMTM8 is one member of this family and has exhibited tumor-inhibiting activities. It can encode proteins approaching to the transmembrane 4 superfamily. CMTM8 is down-regulated in most carcinoma cell lines and tissues. Over-expression of CMTM8 may inhibit the proliferation,migration,and invasion of carcinoma cells. However,the exact mechanism of its anti-tumor activity remains unclear. CMTM8 may be involved in various signaling pathways governing the occurrence and development of tumors. CMTM8 may be a new target in the gene therapies for tumors,while further studies on CMTM8 and its anti-tumor mechanisms are warranted.
