Change of Serum Angiopoietin-like Protein 2 and Its Significance in Patients with Arteriosclerotic Occlusion.
10.3881/j.issn.1000-503X.2017.02.005
- Author:
Yue LIANG
1
,
2
;
Hao NIE
3
;
Hualiang REN
4
;
Fangda LI
3
;
Cui TIAN
5
;
Huihua LI
6
;
Yuehong ZHENG
3
Author Information
1. 1 Department of Vascular Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China
2. 2 Department of Vascular Surgery,Inner Mongolia People's Hospital,Inner Mongolia 010017,China.
3. 1 Department of Vascular Surgery,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
4. 3 Department of Vascular Surgery,Chaoyang Hospital of Beijing Affiliated to Capital Medical University,Beijing 100020,China.
5. 4 Department of Physiology and Physiopathology,Capital Medical University,Beijing 100069,China.
6. 5 Department of Cardiology,Institute of Cardiovascular Diseases,First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning 116011,China
- Publication Type:Journal Article
- From:
Acta Academiae Medicinae Sinicae
2017;39(2):188-195
- CountryChina
- Language:English
-
Abstract:
Objective To investigated the changes of angiopoietin-like protein 2(Angptl2) in patients with arteriosclerotic occlusion (ASO). Methods A total of 140 subjects including 75 ASO patients (ASO group) and 65 healthy subjects (control group) were enrolled in this study. Angptl2 and adiponectin were evaluated by using enzyme-linked immunosorbent assay. Biochemical data and high sensitive C reactive protein were measured and recorded as well. Results Compared to the control group,the ASO group presented with significantly higher level of plasma Angptl2 [(13.55±9.17) μg/L vs. (9.04±4.79) μg/L,P=0.010]. Plasma Angptl2 level of critical limb ischemia subjects was significantly higher than that of intermittent claudication subjects [(17.01±10.20)μg/L vs. (10.53±6.97) μg/L,P=0.003]. The best diagnostic cutoff value of Angptl2 was 13.67 μg/L,with a sensitivity of 60.34% and a specificity of 81.25%. In addition,type 2 diabetes mellitus patients with ASO exhibited significantly higher serum Angptl2 levels [(18.67±9.84)μg/L] than those without ASO [(13.01±3.47) μg/L] (P=0.021). In ASO group,serum Angptl2 levels were negatively correlated with ankle brachial index (r=-0.244,P=0.035). Conclusion The plasma level of Angptl2 increases in ASO patients. Its level is remarkably increased when the disease progressions to critical limb ischemia. Angptl2 can be a potential biological marker of disease progression.
