Clinical Analysis of 122 Cases of Langerhans Cell Histiocytosis.
10.3881/j.issn.1000-503X.2017.02.007
- Author:
Tao WANG
1
;
Beibei SU
2
;
Dawei HAN
1
;
Anli TONG
3
;
Jian LI
4
;
Yuehua LIU
1
;
Hongzhong JIN
1
;
Kai FANG
1
Author Information
1. Department of Dermatology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
2. 1 Department of Dermatology, PUMC Hospital,CAMS and PUMC,Beijing 100730,China
3. Department of Endocrinology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
4. Department of Hematology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
- Publication Type:Journal Article
- From:
Acta Academiae Medicinae Sinicae
2017;39(2):206-210
- CountryChina
- Language:English
-
Abstract:
Objective To investigate the features of Langerhans cell histiocytosis (LCH). Method Skin lesions,systemic involvement,imaging characteristics,laboratory tests,immunophenotying,treatment response,and survival of 122 LCH patients treated at our center from February 1983 to August 2013 were retrospectively analyzed. Results LCH was associated with diverse skin lesions. Lung was the most involved organ,followed by bone,skin,lymph nodes,liver,spleen,oral cavity,and thyroid. Multisystem LCH was more common than single-system LCH. Single-system LCH was mostly treated by surgery,whereas multisystem LCH by combined chemotherapy. Conclusion LCH has diverse clinical manifestations,with lungs being the most often involved organ. Surgery or chemotherapy is the mainstream treatment.
