New dammarane type triterpene with cyclization at the side chain from oxidative alkaline-degradation products of PQS.
- Author:
Yuan HUANG
1
;
Ning LI
;
Xian LI
;
Lu-Sha GAO
;
Da-Li MENG
Author Information
1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
- Publication Type:Journal Article
- MeSH:
Cyclization;
Oxidation-Reduction;
Panax;
chemistry;
Sapogenins;
chemistry;
Saponins;
chemistry;
Steroids;
chemistry;
Triterpenes;
chemistry
- From:
Acta Pharmaceutica Sinica
2008;43(3):277-280
- CountryChina
- Language:Chinese
-
Abstract:
To study the oxidative alkaline-degradation products of PQS (Panax quinquefolium saponin), two compounds were isolated from the crude product of oxidative alkaline-degradation by silica gel column chromatography, Sephadex LH-20 column chromatography and recrystallized methods. On the basis of spectroscopic analysis, their structures were established as (12R, 20S, 24R)-20, 24; 12, 24-diepoxy-24-deisopropyl-dammarane-3beta-ol (1) and (20S, 24R)-20, 24-epoxydammarane-3beta3, 12beta, 25-triol (2). Compounds 1 and 2, dammarane type triterpene with cyclization at the side chain, were obtained for the first time from alkaline-degradation products of total ginsenosides of Panax quinquefolium L., compound 1 is a new compound.
