Electrochemical behaviour of the adriamycin on the cobalt nanoparticles modified ITO electrode.
- Author:
Lan-Xin GONG
1
;
Cui-Mei WEI
;
Jin-Bo HU
;
Qi-Long LI
Author Information
1. School of Life Science and Chemistry, Xinjiang Normal University, Urumchi 830054, China.
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents;
chemistry;
pharmacology;
Clinical Laboratory Techniques;
Cobalt;
chemistry;
Doxorubicin;
chemistry;
pharmacology;
Electrochemistry;
Electrodes;
trends;
Nanoparticles;
chemistry
- From:
Acta Pharmaceutica Sinica
2008;43(3):303-307
- CountryChina
- Language:Chinese
-
Abstract:
A cobalt nanoparticles modified ITO electrode (NpCo/ITO) was prepared by casting cobalt nanoparticles onto ITO electrode and the cobalt nanoparticles were synthesized by NaHB4 reduction. The electrochemical behaviors of adriamycin (ADM) on NpCo/ITO were studied. The modified ITO electrode was characterized by cyclic voltammetry (CV), scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS). In a 0.01 mol L(-1) PBS (pH 8.0) buffer solution, a sensitive reduction peak of ADM was obtained. A linear relationship is held between the peak current and ADM concentration in the range of 1.0 x 10(-8) - 2.0 x 10(-6) mol L(-1) with detection of 5.0 x 10(-9) mol L(-1)- by cyclic voltammetry (CV) response. The reduction process was irreversible with adsorption at the NpCo/ITO electrode. The modified electrode showed an excellent electrocatalytic activity for the ADM electrochemical reduction.
