Signal transduction by protein tyrosine kinases and antitumor agents.
- Author:
Yong-Jun MAO
1
;
Hai-Hong LI
;
Jian-Feng LI
;
Jing-Shan SHEN
Author Information
1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Antineoplastic Agents;
pharmacology;
Humans;
Phosphatidylinositol 3-Kinases;
metabolism;
Protein-Tyrosine Kinases;
metabolism;
Receptor Protein-Tyrosine Kinases;
metabolism;
STAT Transcription Factors;
metabolism;
Signal Transduction;
drug effects;
ras Proteins;
metabolism;
src-Family Kinases;
metabolism
- From:
Acta Pharmaceutica Sinica
2008;43(4):323-334
- CountryChina
- Language:Chinese
-
Abstract:
Intracellular signal transduction plays an important role in the process of cellular metabolism, segmentation, differentiation, biological behaviour and cell death. Overactive signal transduction relates to tumor development and progression. Signaling pathways operated by protein tyrosine kinases (PTKs) will be illuminated here briefly. The Ras/Raf/MAPK and PI-3K/Akt pathways through receptor protein tyrosine kinases (RTKs), the Src, Bcr-Abl and JAK/STAT pathways by non-receptor protein tyrosine kinases (nrPTKs) are shown separately. Antitumor agents targeting the key proteins involved in the above five signalling routes are also summarized in this review.
