Advance of several types of important marine antitumor drugs.
- Author:
Jian-Ye ZHANG
1
;
Li-Wu FU
Author Information
1. State Key laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, 510060, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Antineoplastic Agents;
pharmacology;
therapeutic use;
Apoptosis;
drug effects;
Biological Products;
isolation & purification;
pharmacology;
therapeutic use;
Bryostatins;
isolation & purification;
pharmacology;
therapeutic use;
Cell Line, Tumor;
drug effects;
Depsipeptides;
isolation & purification;
pharmacology;
therapeutic use;
Dioxoles;
isolation & purification;
pharmacology;
therapeutic use;
Disulfides;
isolation & purification;
pharmacology;
Ethers, Cyclic;
isolation & purification;
pharmacology;
Humans;
Macrolides;
Marine Biology;
Neoplasms;
drug therapy;
pathology;
Tetrahydroisoquinolines;
isolation & purification;
pharmacology;
therapeutic use;
Tyrosine;
analogs & derivatives;
isolation & purification;
pharmacology
- From:
Acta Pharmaceutica Sinica
2008;43(5):435-442
- CountryChina
- Language:Chinese
-
Abstract:
Marine antitumor drugs have been the research focus in the world. Recently, advancement has been made in the investigation of six types of compounds including bryostatin-1, ecteinascidin-743, dolastatin, didemnin B, psammaplin and halichondrin B. In this review, we summarized the recent research progress of the above mentioned marine antitumor drugs and their derivatives. Also, the development tendency of marine antitumor drugs was discussed.
