Design and synthesis of a type of benzopyran derivatives with insulin-sensitizing activity.
- Author:
Lei TANG
1
;
Yu LI
;
Juan-Hong YU
;
Yu-She YANG
;
Ru-Yun JI
Author Information
1. School of Pharmacy, Guiyang Medical College, Guiyang 550004, China. tlei1974@hotmail.com
- Publication Type:Journal Article
- MeSH:
3T3-L1 Cells;
Animals;
Benzopyrans;
chemical synthesis;
pharmacology;
Drug Design;
Hypoglycemic Agents;
chemical synthesis;
pharmacology;
Insulin;
pharmacology;
Mice
- From:
Acta Pharmaceutica Sinica
2008;43(6):605-610
- CountryChina
- Language:Chinese
-
Abstract:
Ten novel compounds were designed and synthesized on the basis of compound 1, their insulin-sensitizing activities were evaluated in 3T3-L1 cells. Results showed that compound 10 exhibited strong differentiation-stimulating activity on 3T3-L1 cells model, which indicated that compound 10 may possess well insulin-sensitizing activity.
