A follow-up study on children conceived through intracytoplasmic sperm injection
10.3760/cma.j.issn.0254-6450.2010.08.022
- VernacularTitle:卵胞浆内单精子显微注射子代临床随访研究
- Author:
Mu-Xue YU
1
;
Yan-Wen XU
;
Can-Quan ZHOU
;
Si-Qi ZHUANG
;
Zi-Lian WANG
;
Wei-Qi CHEN
;
Xiao-Yu LI
;
Ming-Fen DENG
Author Information
1. 中山大学附属第一医院
- Keywords:
Intracytoplasmic sperm injection;
Perinatal period;
Multiple pregnancies;
Birth defect
- From:
Chinese Journal of Epidemiology
2010;31(8):929-932
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the perinatal complications, birth defects and growth of children conceived through intracytoplasmic sperm injection (ICSI). Methods A total of 575 children conceived by ICSI in our reproductive medical center, were studied. The follow-up study would include items as pregnant complications, neonatal complications, birth defects in perinatal period, subsequently detected birth defects, body weight and body length/height growth. Results Prematurity and low birth weight of ICSI children were higher in the multiple births than in the singleton births. The rates of materal gestational hypertension, neonatal asphyxia, respiratory distress syndrome, infection diseases were higher in the multiple pregnancies than in the singleton pregnancies(P＜0.05). Eleven ICSI children had died. Ten of them died in the neonatal period and they were preterm infants. One fullterm singleton ICSI child died of hepatoblastoma at the age of 2. The rate of birth defects in perinatal period was higher in ICSI children of multiple pregnancies than in the general population (P＜0.05). The body weight and body length/height of most ICSI children had obtained the standard range between 1 to 3 year-olds. Conclusion The higher rates of perinatal complications in ICSI children were closely related to multiple pregnancies.
